Sickle Cell Gene Distribution

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Anthropological Implications of Sickle Cell Gene Distribution in West Africa1

URING the past fifteen years, data on the frequency of the sickle cell D gene have accumulated to such an extent that its world distribution can now be outlined in considerable detail. Frequencies of more than 20 percent of ‘the sickle cell trait have been found in populations across a broad belt of tropical Africa from the Gambia to Mozambique. Similar high frequencies have been found in Greec...

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Beta-Globin Gene Cluster Haplotypes in Iranian Sickle Cell Patients: Relation to Some Hematologic

Background: Sickle cell anemia is relatively common in Khuzestan province located in Southwest Iran. The characteristics of sickle cell disease in Iran are apparently different from other regions some of these characteristics might be related to β-chain haplotypes. The purpose of this study was to determine the frequency of β-chain haplotypes in 50 patients with homozygous sickle cell anemia in...

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Red cell distribution width in sickle cell disease.

Red cell distribution width (RDW), an electronically determined index of anisocytosis, was examined in 60 patients with sickle cell anemia (Hb SS), 28 patients with hemoglobin sickle cell (SC) disease, and seven patients with sickle cell-beta(+) thalassemia (S-thal). All patients were adults and in the steady state of their disease. The RDW was greater in sickle cell patients than in 39 healthy...

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Intracardiac Thrombosis in Sickle Cell Disease

In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive...

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ژورنال

عنوان ژورنال: Nature

سال: 1955

ISSN: 0028-0836,1476-4687

DOI: 10.1038/176963a0